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20 SEPT 2026
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Every article, newest first. News, analysis, regulation, trial data and compound updates.

30 Jun
Regulation

FDA reshapes testosterone labeling: cardiovascular boxed warning gone, blood-pressure warning added, prostate-cancer contraindication narrowed

After the TRAVERSE trial found no excess cardiovascular risk, the FDA's 2025 class-wide relabeling removed the decade-old boxed warning; a June 2026 request goes further, proposing to add a blood-pressure warning and loosen the age-related-hypogonadism and prostate-cancer restrictions.

enwy30 Jun0 commentsPartly confirmedPartly confirmedThe central claim is traced to a cited source, but some specific figures or details in this piece could not be independently confirmed. Details that fall into that category are marked in the text.Specifically unconfirmedThe February 2025 class-wide change (boxed-warning removal, TRAVERSE addition, ABPM blood-pressure warning) is well established. The June 2026 items are FDA-requested/proposed label revisions and may not yet be finalized in every product's approved labeling; exact effective dates and final wording were not confirmed from the FDA primary notice, which returned errors to automated retrieval. TRAVERSE MACE figures (~7.0% vs ~7.3%, n>5,200, ~33-month mean follow-up) are drawn from secondary summaries of the trial rather than the NEJM primary text. The date field reflects the mid-2026 proposal window.
15 Apr
Analysis

BPC-157 and TB-500: the 'healing peptide' hype versus the human evidence

Two injury-recovery peptides dominate fitness TikTok, but the human clinical data behind them is essentially nonexistent.

enwy15 Apr0 commentsPartly confirmedPartly confirmedThe central claim is traced to a cited source, but some specific figures or details in this piece could not be independently confirmed. Details that fall into that category are marked in the text.Specifically unconfirmedEfficacy claims for both peptides are supported mainly by animal data; human clinical evidence is minimal to absent, so all human-benefit claims are marked partial/unconfirmed. Contamination and mislabeling figures come from clinician reporting of third-party testing rather than a single peer-reviewed dataset.
5 Mar
Analysis

Tongkat ali and fadogia agrestis went viral as 'natty test boosters' — only one has human safety data

A podcast-driven supplement stack pairs a herb with real randomised trials against one whose entire evidence base is a handful of rat studies, some showing organ toxicity.

enwy5 Mar0 commentsPartly confirmedPartly confirmedThe central claim is traced to a cited source, but some specific figures or details in this piece could not be independently confirmed. Details that fall into that category are marked in the text.Specifically unconfirmedTongkat ali human RCTs and the LiverTox rating/case report are confirmed (LiverTox NBK609015 fetched directly). Fadogia agrestis claims — no human studies, rat testosterone rise plus 28-day testicular/organ toxicity from a single research group, and the Huberman podcast as the popularity driver — are corroborated across multiple secondary summaries but not verified against the original University of Ilorin rodent papers; confidence set PARTIAL accordingly.
15 Dec
Analysis

Methylene blue: a century-old dye goes viral for longevity claims it can't support

Biohackers and celebrities have made the blue liquid a TikTok fixture, but there is no clinical evidence for the cognitive and anti-aging claims — and a real drug-interaction risk.

enwy15 Dec0 commentsUnconfirmedUnconfirmedThis is being reported by the cited source, but we have not been able to confirm it independently. It is published because it is worth knowing about, not because it has been established. Treat it as a report, not a fact.Specifically unconfirmedLongevity and cognitive-enhancement claims are unconfirmed in humans; only preclinical/laboratory data exist. RFK Jr.'s blue liquid was never confirmed to be methylene blue. The ~13% SSRI-use figure is reporting-sourced.
1 Dec
Analysis

'Tren' culture meets the data: survey links trenbolone to greater psychological distress

A 2024 study in the International Journal of Drug Policy examined the compound that steroid-using communities themselves rate as the most mentally harmful.

enwy1 Dec0 commentsPartly confirmedPartly confirmedThe central claim is traced to a cited source, but some specific figures or details in this piece could not be independently confirmed. Details that fall into that category are marked in the text.Specifically unconfirmedCardiovascular and neurotoxicity claims rest on case reports, self-report survey data and preclinical studies, not controlled human trials. ScienceDirect full text was not directly accessible; findings confirmed via publisher/institutional summaries and the study's abstract via search.
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