Methylstenbolone (Designer Variant)
A 2,17α-dimethyl DHT-derived designer oral (2,17α-dimethyl-5α-androsta-1-en-17β-ol-3-one) that appeared in pro-hormone supplements alongside dymethazine. Non-aromatising and strongly hepatotoxic; implicated in a published case of cholestatic jaundice.
01 Overview
Methylstenbolone is a methylated relative of stenbolone: a 2,17α-dimethyl-5α-androst-1-ene-3-one structure. It surfaced in "designer" oral supplements in the early 2010s and, like dymethazine, was found in the "Super DMZ" product line that drove FDA action and a documented liver-injury case. This entry covers the grey-market variant as sold, distinct from the base methylstenbolone chemistry.
Being 5α-based and non-aromatising, it produces "dry" gains, but the twin methyl substitutions make it markedly hepatotoxic and strongly suppressive. Human data are limited to marketing anecdote and adverse-event reports.
02 Mechanism
Androgen receptor agonist; 17α-methylation gives oral bioavailability, the 2-methyl and Δ1 features resist metabolism and prevent aromatisation, so effects are purely androgenic/anabolic with no estrogen conversion.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Label / anecdotal | 8–16 mg/day | Oral | From former product labels; no clinical basis. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Dry strength and lean massAnecdotal rapid strength and hardness with minimal water retention. | Unquantified | Anecdotal | |
| No aromatisationStructure cannot aromatise, avoiding estrogenic bloat and gynecomastia. | Non-estrogenic | Preclinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Cholestatic hepatotoxicityNamed alongside dymethazine in a cholestatic-jaundice case report. | Severe | Common | Observational | |
| Severe HDL suppressionDry non-aromatising orals sharply lower HDL cholesterol. | Moderate | Very common | Anecdotal |