Anabolic steroidAndrogenDHT-derivedOralDesigner steroid17-alkylated

Dimethandrostanol (Dymethazine)

Also known as Dymethazine · DMZ · Mebolazine · Roxilon

Written by enwyReviewed 5 Aug 20261 sources0 comments

An azine-linked dimer of methasterone (superdrol) sold as a "designer" oral supplement in the late 2000s. The azine bond cleaves in the body to release two active methasterone-like molecules. Linked in case reports to cholestatic liver injury.

01 Overview

Dimethandrostanol, better known as dymethazine or mebolazine (2α,17α-dimethyl-5α-androstan-17β-ol-3-one azine), is two methasterone units joined by an azine (=N–N=) bridge. The bridge acts as a slow-release linker: the body must first cleave it, after which the compound behaves essentially as methasterone. It appeared as a labelled ingredient in products such as "Super DMZ" and drew FDA enforcement.

Human evidence is confined to marketing-era anecdote and adverse-event case reports. A published case describes cholestatic jaundice in a user of a supplement containing dymethazine and methylstenbolone, consistent with the known hepatotoxicity of 17-alkylated DHT derivatives.

02 Mechanism

Prodrug dimer: azine cleavage yields two molecules of a methasterone-like 17α-methyl-5α-androstane androgen that agonise the androgen receptor. Being 5α-reduced it does not aromatise.

03 Dosing

Tier	Dose	Route	Notes
Label / anecdotal	10–30 mg/day	Oral	Reflects former product labels; no clinical dosing exists.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Rapid strength and lean massUsers reported dry gains similar to methasterone; no controlled data.	Unquantified	Anecdotal
No estrogenic activity5α-reduced structure cannot aromatise, so gains present as dry with minimal water retention.	Non-aromatising	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Cholestatic liver injuryCase report of cholestatic jaundice tied to a dymethazine-containing supplement.	Severe	Common with alkylated orals	Observational
Blood pressure and lipid strainMarked HDL suppression and hypertension reported with dry oral DHT-derivatives.	Moderate	Common	Anecdotal

06 Legal status

United States

Schedule III controlled

Captured as an anabolic steroid; subject of FDA enforcement against supplements. · as of Jan 2026

WADA S1 anabolic agent

as of Jan 2026

07 References

Cholestatic Jaundice With the Use of Methylstenbolone and Dymethazine, Designer Steroids Found in Super DMZ Rx 2.0Journal of Investigative Medicine High Impact Case Reports, 2015

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.