Ethylescaline (EscEt)
Ethylescaline (4-ethoxy-3,5-dimethoxyphenethylamine, EscEt) is a scaline mescaline analogue in which the 4-methoxy of mescaline is replaced by an ethoxy group. Shulgin reported a clear, longer-lasting psychedelic somewhat more potent than mescaline.
01 Overview
Ethylescaline belongs to the 'scaline' family of mescaline homologues alongside escaline and proscaline. Lengthening the 4-alkoxy group from methoxy to ethoxy raises potency several-fold over mescaline while retaining a gentle, mescaline-like character.
Human use is uncommon and confined to research-chemical circles. No toxicology exists, and its mescaline-type sympathomimetic profile means the usual cardiovascular cautions apply.
02 Mechanism
5-HT2A partial agonist; the 4-ethoxy substitution increases lipophilicity and receptor potency relative to mescaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 20–40 mg | Oral | |
| Common | 40–80 mg | Oral | Duration 8-12 hours. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mescaline-like psychedeliaWarm visuals and emotional openness resembling mescaline. | moderate | Anecdotal | |
| Body-centred euphoriaPleasant physical tone reported at common doses. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset nausea typical of scalines and mescaline. | Mild | Common | Anecdotal | |
| Vasoconstriction/tachycardiaRaised heart rate and mild vasoconstriction from the phenethylamine core. | Moderate | Common | Anecdotal |