Research chemicalResearch chemicalPhenethylaminePsychedelic
Proscaline
Also known as 3-propoxy-4,5-dimethoxyphenethylamine
Proscaline is the 3-propoxy analogue of mescaline, a synthetic scaline psychedelic documented in PiHKAL. It is more potent than mescaline and produces a long visual and euphoric experience, with minimal formal human study.
01 Overview
Proscaline extends the escaline series by one carbon, using a propoxy group in place of the 3-methoxy of mescaline. Reported effects include strong visuals, euphoria and stimulation over roughly 8-12 hours.
As with the other synthetic scalines, human information is confined to self-experiments and anecdotal reports. Effects and safety are poorly characterised.
02 Mechanism
Agonist at serotonin 5-HT2A receptors; the propoxy substitution confers higher potency than mescaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 10–20 mg | Oral | |
| Common | 20–60 mg | Oral | PiHKAL range. |
| Strong | 60–90 mg | Oral |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual enhancementBright colour and pattern intensification. | Anecdotal | ||
| Euphoria and stimulationReported mood elevation with mild energetic quality. | Anecdotal | ||
| Long durationFull-day experience. | 8-12 h | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset queasiness. | Mild | Common | Anecdotal | |
| Sympathomimetic stimulationPresumed increase in heart rate and blood pressure. | Mild | Common | Unconfirmed | |
| AnxietyAnxiety or unease at higher doses. | Moderate | Dose-dependent | Anecdotal |
06 Legal status
United Kingdom
Class A
as of Jan 2026
United States
Unscheduled
Possible Analogue Act coverage. · as of Jan 2026
07 References
PiHKAL: A Chemical Love Story (Proscaline entry)Shulgin A. & Shulgin A., 1991
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.