Escaline
Escaline is a synthetic scaline psychedelic, the 3-ethoxy analogue of mescaline. It is more potent than mescaline by weight and produces a comparable long-duration psychedelic experience, but has little formal human study.
01 Overview
Escaline replaces the 3-methoxy group of mescaline with an ethoxy group, raising potency several-fold. Documented in Alexander Shulgin's PiHKAL, its effects are described as visual, euphoric and emotionally engaging over an 8-12 hour course.
Human data are limited to self-experiment reports and anecdote. Duration and dose-sensitivity mirror the wider scaline family, and reported effects should be treated as poorly characterised.
02 Mechanism
Serotonin 5-HT2A receptor agonist, like other scalines; the ethoxy substitution increases receptor affinity and potency relative to mescaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 10–20 mg | Oral | |
| Common | 20–60 mg | Oral | PiHKAL range. |
| Strong | 60–100 mg | Oral |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual enhancementColour and pattern enhancement building over 1-2 hours. | Anecdotal | ||
| Euphoria and sociabilityReported mood lift and mild stimulation. | Anecdotal | ||
| Long durationFull-day experience typical of scalines. | 8-12 h | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset-phase queasiness. | Mild | Common | Anecdotal | |
| Elevated heart rate and blood pressureSympathomimetic stimulation inferred from related phenethylamines. | Mild | Common | Unconfirmed | |
| AnxietyAcute anxiety at higher doses. | Moderate | Dose-dependent | Anecdotal |