Methyldienolone
A potent 17alpha-methylated 19-nor designer steroid (a diene analogue of methyltrienolone/metribolone chemistry) marketed briefly in gray-market products. Highly potent in preclinical assays but essentially no human safety data and notable hepatotoxicity risk.
01 Overview
Methyldienolone (17alpha-methyl-estra-4,9(10)-dien-17beta-ol-3-one family) is an orally active 19-nor androgen closely related to the extremely potent research steroid methyltrienolone. It appeared in unregulated 'designer prohormone' products before being controlled.
No formal human pharmacology exists. Its reputation for potency comes from receptor-binding assays and its close structural kinship to metribolone, a compound so toxic it is used only as a laboratory reference.
02 Mechanism
Extremely high-affinity androgen-receptor agonist of the 19-nor family; C17 methylation gives oral activity and the diene structure blocks aromatisation.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Anecdotal | 2–10 mg/day | Oral | Reported as very potent per mg; no validated regimen. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| High AR binding affinityBinds the androgen receptor with high affinity in assays. | very high in vitro | Preclinical | |
| Rapid strength gainsUsers report fast strength gains; no measured data. | unquantified | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Hepatotoxicity17alpha-alkylated 19-nor orals carry high liver strain. | Severe | Class-typical | Preclinical | |
| Severe HPTA suppressionPotent androgen strongly suppresses endogenous testosterone. | Severe | Expected | Preclinical |