Anabolic steroidAndrogenProhormoneOralDesigner steroidDiene-dione

Dienedione (3,17-Keto Prohormone)

Also known as Androstadienedione · Diene · Diene prohormone

Written by enwyReviewed 5 Aug 20261 sources0 comments

A grey-market androstadiene-dione prohormone (androsta-3,5-diene-7,17-dione-adjacent dione) marketed as a designer "pro-anabolic" that converts in vivo toward an active androgen. Essentially uncharacterised in humans; sold in supplements after the 2005 and 2014 prohormone crackdowns.

01 Overview

Dienedione is one of the diene-dione prohormones that proliferated in supplements marketed as "legal" anabolics. As a Δ3,5-diene 17-ketone it is presented as a precursor that undergoes hepatic conversion to a more active androgen after ingestion, in the same spirit as the earlier androstenedione and later trendione (trenavar) products.

Human pharmacology is effectively nonexistent: there are no controlled conversion or efficacy studies, and it is known mainly from supplement labels, forum anecdote and anti-doping detection interest. It is captured by anabolic-steroid control laws in the US as a prohormone.

02 Mechanism

Prohormone: an inactive or weakly active Δ-diene 17-ketosteroid proposed to undergo 17β-reduction (and further conversion) to an active androgen that then agonises the androgen receptor.

03 Dosing

Tier	Dose	Route	Notes
Label / anecdotal	30–90 mg/day	Oral	From supplement labels; conversion efficiency and true exposure unknown.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Modest strength / recompositionUsers report mild lean gains typical of prohormones; no controlled data exist.	Unquantified	Anecdotal
Prohormone conversionIn-vivo conversion to an active androgen is assumed but not demonstrated in humans.	Unknown yield	Unconfirmed

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
HPTA suppressionSuppression of natural testosterone reported, as with other prohormones.	Moderate	Common	Anecdotal
Hepatic strainOral prohormones carry uncertain hepatic load depending on conversion pathway.	Moderate	Uncommon	Unconfirmed

06 Legal status

United States

Schedule III controlled

Covered as an anabolic steroid / prohormone under the Designer Anabolic Steroid Control Act 2014. · as of Jan 2026

WADA S1 anabolic agent

as of Jan 2026

07 References

Designer steroids – over-the-counter supplements and their androgenic component: review of an increasing problemAndrology, 2015

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.