Anabolic steroidAndrogenDHT derivativeAnabolic steroidOral17-alpha-alkylatedDesigner steroidAzine dimer

Mebolazine

Also known as Roxilon · Dimethazine (older usage) · DMZ

Written by enwyReviewed 5 Aug 20261 sources0 comments

Mebolazine (dimethazine's chemical cousin; the azine dimer of mestanolone, also called dymethazine in some literature) is an orally active designer steroid formed by joining two mestanolone-like units via a nitrogen-nitrogen azine bridge that hydrolyses in vivo to release active 17-alpha-methyl-DHT. It is a non-aromatising, dry, strongly androgenic and hepatotoxic oral with essentially no controlled human data.

01 Overview

Mebolazine was described in older pharmaceutical literature (as 'roxilon') and later resurfaced as a grey-market prohormone. The azine bridge links two steroid molecules; after ingestion, hydrolysis liberates a mestanolone-type androgen, so the pharmacology tracks that of methylated DHT: no estrogen conversion, a hard/dry effect and marked hepatic strain.

Because it was sold as an unregulated 'designer' oral, human evidence is limited to anecdote and adverse-event reports. It should be regarded as a hepatotoxic 17-alpha-alkylated androgen with an unfavourable androgenic-to-anabolic balance.

02 Mechanism

Prodrug: azine linkage hydrolyses in vivo to release a 17-alpha-methylated DHT-type androgen that binds the androgen receptor; C17-alpha methyl confers oral bioavailability.

03 Dosing

Tier	Dose	Route	Notes
Anecdotal	20–40 mg/day	Oral	Grey-market prohormone dosing; no medical basis.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Dry lean mass/hardnessNon-aromatising androgen giving a hard look without water retention.	modest	Anecdotal
Strength increaseReported strength gains during short cycles.	modest	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Adverse lipid changesSuppressed HDL and raised LDL typical of oral 17-alpha compounds.	Moderate	Common with oral AAS	Observational
HepatotoxicityCase reports of cholestatic liver injury from azine-linked designer orals.	Severe	Common	Anecdotal
HPTA suppressionSuppresses natural testosterone production.	Severe	Universal	Anecdotal

06 Legal status

United Kingdom

Class C

Anabolic steroid. · as of Jan 2026

United States

Schedule III controlled

Captured as an anabolic steroid analogue. · as of Jan 2026

07 References

Designer anabolic steroids: over a half-century of concealed dopingJournal of Steroid Biochemistry and Molecular Biology, 2018

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.