Research chemicalResearch chemicalPhenethylaminePsychedelic
Isoproscaline
Also known as 3-isopropoxy-4,5-dimethoxyphenethylamine
Isoproscaline is the 3-isopropoxy analogue of mescaline, a scaline psychedelic from PiHKAL. It is potent and long-acting, with an unusual reported effect profile weighted toward tactile and emotional rather than visual changes, and very little human data.
01 Overview
Isoproscaline substitutes an isopropoxy group at the 3 position of mescaline. Shulgin's notes describe a heavy body and emotional character with comparatively modest visuals, over a long duration.
Human information is limited to a handful of self-experiments. Its effects and safety profile are essentially uncharacterised.
02 Mechanism
Serotonin 5-HT2A receptor agonist; branched isopropoxy substitution alters potency and subjective character relative to proscaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 20–30 mg | Oral | |
| Common | 30–80 mg | Oral | PiHKAL range. |
| Strong | 80–120 mg | Oral |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Tactile and body enhancementHeavy, warm body feeling described as prominent. | Anecdotal | ||
| Emotional depthIntrospective, feeling-oriented headspace. | Anecdotal | ||
| Long durationExtended experience. | 8-12 h | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset queasiness. | Mild | Common | Anecdotal | |
| Sympathomimetic stimulationPresumed mild cardiovascular stimulation. | Mild | Uncommon | Unconfirmed | |
| AnxietyAnxiety at higher doses. | Moderate | Dose-dependent | Anecdotal |
06 Legal status
United Kingdom
Class A
as of Jan 2026
United States
Unscheduled
Possible Analogue Act coverage. · as of Jan 2026
07 References
PiHKAL: A Chemical Love Story (Isoproscaline entry)Shulgin A. & Shulgin A., 1991
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.