Diethylpropion
A sympathomimetic anorectic (also called amfepramone) used for short-term weight loss. It suppresses appetite via noradrenaline release and is generally considered milder than amphetamine-type anorectics. Indicated for short courses due to tolerance and cardiovascular and dependence considerations.
01 Overview
Diethylpropion (amfepramone) is an anorectic structurally related to bupropion and amphetamine. It is used short-term as an adjunct to diet in obesity and is often regarded as having a somewhat gentler cardiovascular and central-stimulant profile than phentermine, though it still raises heart rate and blood pressure.
It is Schedule IV in the US. As with all anorectics, tolerance to the appetite effect develops, limiting it to brief courses, and dependence is possible. Common effects include dry mouth, insomnia and mild cardiovascular stimulation.
02 Mechanism
Promotes release of noradrenaline in the hypothalamus (largely via its active metabolites) to reduce appetite.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Therapeutic (immediate-release) | 75 mg/day | Oral | 25 mg three times daily before meals, or 75 mg controlled-release once daily. Short-term use. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Appetite suppression and weight lossReduces appetite and supports short-term weight loss with diet. | Modest short-term weight loss | Clinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| InsomniaDifficulty sleeping from CNS stimulation. | Mild | Common | Clinical | |
| Cardiovascular stimulationElevated heart rate and blood pressure; palpitations. | Moderate | Common | Clinical | |
| Tolerance and dependenceAppetite effect diminishes over weeks; dependence possible. | Moderate | Uncommon | Clinical |