4-MPD
4-MPD (4-methyl-alpha-pyrrolidinohexanophenone-adjacent; commonly 4-methyl-pentedrone) is a synthetic cathinone stimulant sold as a research chemical. It combines a 4-methyl ring substituent with a pentedrone-like backbone. Human data is absent; anecdotal reports describe a functional, moderately euphoric stimulant with pronounced redosing.
01 Overview
4-MPD is marketed as a legal-grey cathinone stimulant with no medical use. Users describe a clear-headed, energetic stimulation with some euphoria, positioned between pentedrone and the more empathogenic 4-substituted cathinones.
All class hazards apply: compulsive redosing, cardiovascular strain, comedown and unknown neurotoxicity. There are no human studies; figures below are approximate and anecdotal.
02 Mechanism
Presumed noradrenaline-dopamine reuptake inhibitor with weak releasing activity, typical of alpha-alkylated cathinones.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 40–90 mg | Insufflated | Sharper onset, stronger redose urge. |
| Common | 75–150 mg | Oral | Anecdotal only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| StimulationEnergy, focus and wakefulness. | Anecdotal | ||
| EuphoriaMild to moderate mood elevation. | Anecdotal | ||
| Appetite suppressionReduced hunger. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Compulsive redosingRepeated dosing over a session. | Moderate | Most users | Anecdotal | |
| Cardiovascular strainElevated heart rate and blood pressure. | Severe | Common | Unconfirmed | |
| ComedownFatigue and low mood after use. | Moderate | Common | Anecdotal |