Research chemicalCathinoneStimulantResearch chemical

Pentedrone

Also known as alpha-methylamino-valerophenone · Pentedrone

Written by enwyReviewed 4 Aug 20262 sources0 comments

Pentedrone (alpha-methylamino-valerophenone) is a synthetic cathinone and dopamine/noradrenaline reuptake inhibitor with an open-chain (non-pyrrolidine) structure. It circulated widely as a research chemical and 'bath salts' component. Human pharmacology is uncharacterised; it is a stimulant with strong redosing potential.

01 Overview

Pentedrone is the N-methyl, open-chain analogue related to the pentanophenone cathinones. Users report strong, relatively long-lasting stimulation with limited euphoria, which encourages heavy redosing. It is used orally and by insufflation.

Information is limited to early-warning-system notifications, seizures and intoxication reports, including fatalities in polydrug contexts. Class hazards apply: cardiovascular strain, compulsive redosing, severe comedown, and unconfirmed long-term neurotoxicity.

02 Mechanism

Dopamine and noradrenaline reuptake inhibitor (DAT/NET) with weak serotonergic activity, producing stimulant effects and reinforcement.

03 Dosing

Tier	Dose	Route	Notes
Light	15–40 mg	Insufflated	Faster onset; strong redosing compulsion.
Light	25–50 mg	Oral	Onset ~20-45 min orally.
Common	50–100 mg	Oral	Compulsive redosing common.

04 Effects

Effect	Magnitude	Evidence
Strong stimulationWakefulness, focus and drive with limited euphoria.		Anecdotal
Increased sociabilityTalkativeness and confidence reported.		Anecdotal
Compulsive redosingLimited euphoria and reinforcing profile drive heavy redosing.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Long-term neurotoxicity (unknown)No human data; long-term effects unestablished.	Moderate	Unknown	Unconfirmed
Cardiovascular strainTachycardia, palpitations and hypertension reported in intoxications.	Severe	Common	Observational
Severe comedown and dependenceCraving, low mood and exhaustion after binges; dependence reported.	Severe	Very common	Observational

06 Legal status

United Kingdom

Class B

Covered by the UK cathinone generic definition. · as of Jan 2026

United States

Possibly analogue-controlled

May fall under the Federal Analogue Act; scheduling varies by state. · as of Jan 2026

07 References

EU Early Warning System notifications on synthetic cathinonesEUDA / EMCDDA

Synthetic cathinones: chemistry, pharmacology and toxicologyPubMed review

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.