4-HO-DET (Ethocin / CZ-74)
4-HO-DET (CZ-74) is the diethyl analog of psilocin, a psychedelic tryptamine originally synthesised by Hofmann and Troxler at Sandoz. It produces a shorter psilocybin-like experience. Some mid-century clinical exposure exists but modern data is anecdotal.
01 Overview
4-HO-DET (ethocin, code CZ-74) was made at Sandoz alongside psilocybin and CEY-19 (4-HO-DMT). It is the 4-hydroxy diethyl tryptamine, directly analogous to psilocin, and was investigated briefly in psychiatric settings for a shorter-acting psychedelic than psilocybin.
Contemporary use is as a rare research chemical. Beyond the limited historical clinical work, dosing and safety information rests on self-reports and structural analogy.
02 Mechanism
Serotonin 5-HT2A receptor agonist, the active-form mechanism shared with psilocin.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 10–15 mg | Oral | Anecdotal / historical. |
| Common | 15–30 mg | Oral | Anecdotal / historical. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Shorter psilocybin-like experienceVisual and cognitive alteration of shorter duration than psilocybin. | moderate | Anecdotal | |
| EuphoriaPositive mood shift reported. | mild-moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaGut discomfort at onset. | Mild | Common | Anecdotal | |
| AnxietyFear or unease during the experience. | Moderate | Common | Anecdotal |