Research chemicalResearch chemicalPsychedelicTryptamine

4-HO-DET

Also known as 4-Hydroxy-DET · CZ-74 · Ethocin

Written by enwyReviewed 15 Jul 20261 sources0 comments

4-HO-DET (4-hydroxy-N,N-diethyltryptamine, ethocin/CZ-74) is a synthetic tryptamine psychedelic and the diethyl homologue of psilocin. It was among the tryptamines investigated by Hofmann and colleagues at Sandoz in the 1950s-60s, giving it slightly more historical pharmacological attention than most grey-market tryptamines, though modern controlled data remain minimal.

01 Overview

4-HO-DET, also known as CZ-74 or ethocin, is closely related to psilocin, differing by N,N-diethyl substitution. Its phosphorylated form, CEY-19, is analogous to psilocybin. Sandoz researchers characterised these compounds during early psychedelic research, noting a shorter duration than psilocybin.

Modern use is as a grey-market research chemical with anecdotal reports of a psilocin-like but shorter experience. Formal pharmacokinetic and safety data in humans remain limited.

02 Mechanism

Serotonin 5-HT2A receptor agonist, as with other 4-hydroxy tryptamine psychedelics; the 4-hydroxy group confers oral activity.

03 Dosing

Tier	Dose	Route	Notes
Light	10–20 mg	Oral	Anecdotal; historical Sandoz work used comparable ranges.
Common	20–35 mg	Oral	Anecdotal; shorter duration than psilocybin.

04 Effects

Effect	Magnitude	Evidence
Short-duration psychedeliaPsilocin-like effects with a shorter duration, per historical and anecdotal accounts.	~3-4 hours	Anecdotal
Visual distortionColour enhancement and visual effects reported.	Dose-dependent	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Transient cardiovascular stimulationModest heart rate and blood pressure increases reported.	Mild	Unknown	Anecdotal
AnxietyAnxiety possible at higher doses.	Moderate	Unknown	Anecdotal

06 Legal status

United States

Not explicitly scheduled

Potentially covered by the Federal Analogue Act if intended for human consumption. · as of Jan 2026

07 References

TiHKAL: Tryptamines I Have Known And LovedShulgin & Shulgin, 1997

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.