Research chemicalResearch chemicalPhenethylaminePsychedelic
3C-E
Also known as 3C-Escaline · 1-(3-ethoxy-4,5-dimethoxyphenyl)propan-2-amine
3C-E is a psychedelic phenethylamine of the scaline family, the alpha-methylated (amphetamine) homologue of escaline. It is potent, deeply psychedelic and long-acting, with a reputation for intensity and little formal human study.
01 Overview
3C-E adds an alpha-methyl group to escaline, placing it structurally between the scalines and amphetamine psychedelics. PiHKAL describes it as strongly psychedelic and profound, with intense visuals and a demanding headspace over 8-12 hours.
Human data are anecdotal. Reports emphasise potency and a heavier, sometimes challenging character relative to mescaline. Safety is not established.
02 Mechanism
Serotonin 5-HT2A receptor agonist; alpha-methylation increases metabolic stability and potency relative to escaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 10–20 mg | Oral | |
| Common | 20–50 mg | Oral | PiHKAL range. |
| Strong | 50–70 mg | Oral |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Intense visualsStrong, immersive visual patterning. | Anecdotal | ||
| Deep psychedelic headspaceProfound cognitive alteration, reported as demanding. | Anecdotal | ||
| Long durationFull-day experience. | 8-12 h | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset queasiness. | Mild | Common | Anecdotal | |
| Sympathomimetic stimulationPresumed increase in heart rate and blood pressure. | Mild | Common | Unconfirmed | |
| Anxiety and challenging experiencesIntensity can tip into fear or confusion, especially above common doses. | Moderate | Dose-dependent | Anecdotal |
06 Legal status
United Kingdom
Class A
as of Jan 2026
United States
Unscheduled
Possible Analogue Act coverage. · as of Jan 2026
07 References
PiHKAL: A Chemical Love Story (3C-E entry)Shulgin A. & Shulgin A., 1991
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.