TMA-2
TMA-2 (2,4,5-trimethoxyamphetamine) is a mescaline-related trimethoxy amphetamine psychedelic, notably more potent than mescaline. Described by Shulgin, it produces a long, visual psychedelic experience and is uncommon as a research chemical.
01 Overview
TMA-2 is one of six positional isomers of trimethoxyamphetamine and the most active. It is roughly an order of magnitude more potent than mescaline, with a long duration of eight to twelve hours. It has some historical pharmacology work but no modern clinical use.
Human data are limited to old dosing accounts and anecdote. Its amphetamine backbone brings sympathomimetic and vasoconstrictive potential, and no formal toxicology exists.
02 Mechanism
5-HT2A partial agonist; the 2,4,5-trimethoxy substitution pattern with an alpha-methyl group gives higher potency and longer action than mescaline.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 5–10 mg | Oral | |
| Common | 20–40 mg | Oral | Duration 8-12 hours. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mescaline-like visualsRich colour and geometric visuals over a long plateau. | strong | Anecdotal | |
| Emotional/euphoric toneWarm, sometimes euphoric mood reported at common doses. | moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| NauseaOnset nausea typical of mescaline-type compounds. | Mild | Common | Anecdotal | |
| Vasoconstriction and tachycardiaRaised heart rate, blood pressure and cold extremities from the sympathomimetic amphetamine core. | Moderate | Common | Anecdotal |