TH-PVP
TH-PVP (3',4'-tetramethylene-alpha-pyrrolidinovalerophenone; also read as a tetrahydronaphthalene-fused PVP) is a fused-ring pyrrolidine synthetic cathinone related to alpha-PVP and naphyrone. Sold as a research chemical, it is presumed to be a potent dopamine reuptake inhibitor. Human data is essentially absent and all information is anecdotal.
01 Overview
TH-PVP is a ring-fused analogue in the alpha-PVP/naphyrone lineage, marketed as a legal-grey stimulant. The additional fused ring, as in naphyrone, is associated in reports with a potent, long-lasting and highly compulsive stimulant character.
As a pyrrolidine cathinone with a fused-ring structure it carries a heightened risk of compulsive redosing and binge use, plus cardiovascular strain, comedown and unknown neurotoxicity. No controlled human studies exist; figures are approximate.
02 Mechanism
Presumed potent noradrenaline-dopamine reuptake inhibitor at the dopamine and noradrenaline transporters, with the fused ring system resembling naphyrone.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 5–15 mg | Insufflated | Extremely compulsive. |
| Common | 8–25 mg | Oral | Anecdotal; potent, start very low. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Intense stimulationStrong, long-lasting energy and focus. | Anecdotal | ||
| EuphoriaDopaminergic mood elevation. | Anecdotal | ||
| Appetite suppressionMarked hunger reduction. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Compulsive redosingStrong, hard-to-resist redosing compulsion typical of the PVP/naphyrone series. | Severe | Near universal | Anecdotal | |
| Cardiovascular strainSustained tachycardia and hypertension. | Severe | Common | Unconfirmed | |
| Stimulant psychosisParanoia and hallucinations after prolonged binges and sleep loss. | Severe | Uncommon | Unconfirmed |