PRO-LAD
PRO-LAD (6-propyl-6-nor-LSD) is an LSD analogue with a propyl group at the N6 position. It is a potent psychedelic of roughly LSD-like potency, described in early structure-activity research but essentially uncharacterised in humans beyond anecdote.
01 Overview
PRO-LAD belongs to the family of N6-substituted nor-LSD analogues explored in academic work on the lysergamide scaffold. It is far less common on the market than AL-LAD or the 1-acyl prodrugs, but appears sporadically as blotter.
User reports describe an experience close to LSD in quality and duration. There are no human clinical trials; dose and effect information is anecdotal and inferred from animal drug-discrimination and receptor studies.
02 Mechanism
Partial agonist at 5-HT2A and related serotonin receptors; N6-propyl substitution modifies receptor interaction relative to LSD.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 10–20 mcg | Sublingual | Microdose range. |
| Common | 100–175 mcg | Sublingual | Full psychedelic dose; broadly LSD-comparable. |
| Strong | 175–300 mcg | Oral | Strong experience. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Psychedelic visualsGeometric and colour visuals reported as LSD-like. | 6-9 h | Anecdotal | |
| Mood and cognitive shiftsEuphoria, introspection and altered thought. | Anecdotal | ||
| Anxiety at high dosesParanoia or overwhelm possible, particularly at strong doses. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Sympathomimetic effectsRaised heart rate and blood pressure, mydriasis and tremor. | Mild | Common | Anecdotal | |
| Acute psychological distressAnxiety, paranoia or a difficult experience during acute effects. | Moderate | Common | Anecdotal | |
| Persistent perceptual changes (HPPD)Lasting visual disturbances after use. | Moderate | Rare | Observational |