Omnadren
A four-ester testosterone blend of Polish/Jelfa origin, historically analogous to Sustanon. Original formulations combined testosterone propionate, phenylpropionate, and two longer esters; the modern reformulation mirrors Sustanon 250 exactly. Delivers the full testosterone effect profile with a staggered release from fast to slow esters.
01 Overview
Omnadren is a combination testosterone injectable designed to blend fast- and slow-releasing esters so a single injection produces a quick onset with a long tail. The classic formulation paired testosterone propionate and phenylpropionate with two longer esters (historically caproate/isocaproate and, in older versions, hexahydrobenzylcarbonate variants); today's Omnadren 250 is compositionally equivalent to Sustanon 250 (propionate, phenylpropionate, isocaproate, decanoate).
Because every component is a testosterone ester, the pharmacology is testosterone pharmacology: the blend only shapes the release curve. Steady state builds over several injections as the long esters accumulate. It is well characterised as a testosterone product overall, so the research base is solid for the hormone, though the exact multi-ester kinetics are less rigorously published than single-ester preparations.
02 Mechanism
Each ester is hydrolysed at its own rate by serum esterases, releasing free testosterone that acts through the androgen receptor. Aromatisation to estradiol and 5-alpha reduction to DHT occur normally; the staggered esters produce an early peak followed by sustained levels.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| TRT-equivalent | 250 mg/wk | IM | One ampoule every 1-3 weeks in clinical replacement use. |
| Common | 250–500 mg/wk | IM | Split into 2+ injections weekly to smooth the propionate peaks. |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Increased lean massDose-dependent hypertrophy from released testosterone. | +3-6 kg over a cycle | Clinical | |
| Increased strengthAndrogen-receptor-mediated strength gains. | Clinical | ||
| Fast onset with long tailPropionate/phenylpropionate give early elevation; longer esters sustain levels. | Observational | ||
| Improved libido and moodTypical of restored/elevated testosterone. | Clinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| HPTA suppressionSuppression of LH/FSH and spermatogenesis. | Severe | Universal | Clinical | |
| Estrogenic effectsGynecomastia, water retention, raised blood pressure. | Moderate | Dose-dependent | Clinical | |
| Injection-site pain (propionate)The short propionate ester commonly causes post-injection soreness. | Mild | Common early on | Observational | |
| ErythrocytosisElevated haematocrit. | Moderate | Dose-dependent | Clinical |