O-PCE (Eticyclidone)
O-PCE (eticyclidone, 2-Oxo-PCE) is a potent, stimulating arylcyclohexylamine dissociative sold as a research chemical. It is more potent than ketamine, with a stimulating and dissociative profile similar to a stronger, shorter 3-MeO-PCP, and carries meaningful overdose and psychosis risk.
01 Overview
O-PCE is closely related to eticyclidine and MXE, combining potent NMDA antagonism with a stimulating character. Users report a clear-headed, energetic dissociation at low doses, shading into intense dissociation and confusion as the dose rises. Its potency means small quantities are active and dose errors are easy.
Human data are essentially anecdotal. Reported adverse effects include agitation, tachycardia, mania and psychosis at higher doses, consistent with other stimulating dissociatives.
02 Mechanism
Potent NMDA-receptor antagonist with stimulating properties, likely involving monoamine activity similar to related arylcyclohexylamines.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 3–6 mg | Oral | |
| Common | 5–15 mg | Insufflated | |
| Common | 8–20 mg | Oral | Potent; small dose changes matter. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Stimulating dissociationEnergetic, clear dissociation at lower doses. | Anecdotal | ||
| EuphoriaMood elevation reported at moderate doses. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Overdose and agitationTachycardia, hypertension and agitation; high potency makes overdose easy. | Severe | Common at high doses | Anecdotal | |
| Psychosis and maniaManic states, paranoia and psychosis at higher doses. | Severe | Reported at high doses | Anecdotal |