OtherSympathomimeticPhenethylamineTrace amine
N-Methyltyramine
Also known as NMT · 4-hydroxy-N-methylphenethylamine · N-methyltyramine
N-Methyltyramine (NMT) is a trace amine found in bitter orange and barley, used in fat-burners for mild adrenergic stimulation and appetite/gastric effects. It is often paired with synephrine and hordenine; human data is limited.
01 Overview
N-Methyltyramine is a methylated derivative of tyramine occurring in citrus and cereal grains. In supplements it is promoted for mild energy, fat mobilisation and stimulation of gastrin release (marketed as aiding digestion or 'pump').
Evidence is thin and largely indirect. It is a sympathomimetic and shares the class caution about blood pressure, particularly if combined with MAO inhibitors or other stimulants.
02 Mechanism
Indirect sympathomimetic that promotes noradrenaline release; also stimulates gastrin secretion.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 25–50 mg | Oral | Approximate labelled dose in blends. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mild stimulationLight energy through noradrenaline release. | Mild | Preclinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Blood pressure elevationSympathomimetic pressor effect, worse with MAO inhibitors. | Mild | Uncommon | Preclinical | |
| Gastrointestinal upsetGastric acid stimulation may cause discomfort. | Mild | Uncommon | Anecdotal |
06 Legal status
United States
Sold in supplements
Naturally occurring trace amine. · as of Jan 2026
07 References
N-methyltyramine content of dietary supplements and bitter orangePubMed
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.