PeptideNeuroprotectiveIntranasalNootropic peptide

N-Acetyl Semax Amidate

Also known as NA Semax Amidate · NASA · Acetyl-Semax

Written by enwyReviewed 5 Aug 20261 sources0 comments

N-Acetyl Semax Amidate is a chemically modified, longer-acting analogue of the Russian nootropic peptide Semax, used intranasally for focus and neuroprotection. Human evidence rests on Russian studies of parent Semax plus user anecdote; the modified analogue itself lacks dedicated trials.

01 Overview

Semax is an ACTH(4-10) fragment analogue registered in Russia as a nootropic and used in stroke and cognitive indications. N-Acetyl Semax Amidate adds N-terminal acetylation and C-terminal amidation to slow enzymatic degradation and prolong action, and it is the form most commonly sold to Western nootropic users.\n\nThe original Semax has some Russian clinical data, but the acetyl-amidate analogue has essentially no independent controlled trials of its own. Benefits reported are anecdotal or extrapolated.

02 Mechanism

Modulates BDNF/NGF expression and the melanocortin/ACTH pathway; the acetyl-amidate modifications increase metabolic stability versus native Semax.

03 Dosing

Tier	Dose	Route	Notes
Anecdotal	300–900 mcg/day	Insufflated	Intranasal, split doses; anecdotal nootropic range.

04 Effects

Effect	Magnitude	Evidence
Improved focus and cognitionUsers report sharper focus and mental clarity; parent Semax has limited Russian cognitive data.	n/a	Anecdotal
Neuroprotection / BDNF increaseSemax raises BDNF/NGF in animal models, the basis of neuroprotective claims.	n/a	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Nasal irritationIntranasal use can irritate nasal passages.	Mild	Common	Anecdotal
Overstimulation / irritabilityHigher doses can cause restlessness or irritability in some users.	Mild	Uncommon	Anecdotal

06 Legal status

United States

Research chemical; not FDA-approved

Registered in Russia as Semax; research-only elsewhere. · as of Jan 2026

07 References

Semax, an ACTH(4-10) analogue, and its effects on BDNF and cognitionNeurosci Behav Physiol / Russian clinical literature

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.