MPHP
MPHP (4'-methyl-alpha-pyrrolidinohexiophenone) is a synthetic cathinone stimulant of the pyrrolidinophenone family, a longer-chain, ring-methylated relative of pyrovalerone and alpha-PVP. It circulated as a research chemical with no approved use. Human data is essentially absent; reported effects are anecdotal and describe a potent, long-lasting stimulant with heavy redose pressure.
01 Overview
MPHP belongs to the alpha-pyrrolidinophenone ('pyrro') cathinone class sold as a 'research chemical'. Like alpha-PVP and MDPV it is reported as a strong, focused stimulant with pronounced compulsive redosing and a high risk of stimulant psychosis on binges.
The class hazards apply in full and are amplified in the potent pyrrolidinophenones: compulsive redosing, cardiovascular strain, harsh comedown and unknown neurotoxicity. There are no controlled human studies, so figures are approximate and drawn from user reports.
02 Mechanism
Potent selective inhibitor of dopamine and noradrenaline reuptake with little serotonergic action, typical of the alpha-pyrrolidinophenone cathinones.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 5–20 mg | Insufflated | Faster, stronger, highly compulsive. |
| Common | 10–30 mg | Oral | Anecdotal; potent, easy to overshoot. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| StimulationStrong energy, wakefulness and drive reported by users. | Anecdotal | ||
| Increased focusTask fixation typical of the pyrrolidinophenones. | Anecdotal | ||
| Appetite suppressionMarked reduction in hunger during effects. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Compulsive redosingIntense urge to redose, driving multi-day binges. | Severe | Most users | Anecdotal | |
| Stimulant psychosisParanoia, agitation and hallucinations after prolonged use. | Severe | On binges | Unconfirmed | |
| Cardiovascular strainMarked tachycardia and hypertension. | Severe | Common | Unconfirmed |