Methylboldenone
Methylboldenone (17-alpha-methylboldenone) is an orally active, C17-alpha-alkylated derivative of boldenone. It combines boldenone's diene structure with a methyl group for oral bioavailability, producing a hepatotoxic oral anabolic that surfaced in the grey-market designer/prohormone scene. Human study is essentially absent.
01 Overview
Structurally, methylboldenone is boldenone with a 17-alpha-methyl group; conceptually it is to boldenone what methandienone (Dianabol) is to testosterone. The methylation grants oral activity at the cost of hepatic strain typical of 17-alkylated steroids.
It has no approved veterinary or human product and is known chiefly from designer-steroid seizures and forum reports. Because it is a boldenone relative, its aromatisation to methylated estrogens and its detection profile are of interest to doping laboratories, but rigorous pharmacology is lacking.
02 Mechanism
Androgen-receptor agonist; the 17-alpha-methyl group resists hepatic first-pass metabolism for oral activity, while the 1,2 double bond confers boldenone-like moderate anabolism.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Grey-market anecdotal | 20–40 mg/day | Oral | No validated dosing; based on scattered anecdote |
Ester comparison
| Ester | Half-life | Injection freq. | Testosterone by mass |
|---|
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Lean mass and strength gainReported to produce fairly dry gains similar to a milder oral, though unverified. | Anecdotal | ||
| Oral bioavailability17-alpha-methylation makes an otherwise injectable-class steroid orally active. | Preclinical |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| HPTA suppressionSuppresses endogenous testosterone via androgen feedback. | Moderate | Expected | Observational | |
| Hepatotoxicity17-alpha-alkylated structure causes dose- and duration-dependent liver stress, including raised transaminases and cholestasis risk. | Severe | Typical of 17-alkylated orals | Observational |