Research chemicalResearch chemicalDissociativeArylcyclohexylamine

Methoxetamine (MXE)

Also known as MXE · Mexxy · M-ket · Roflcoptr

Written by enwyReviewed 4 Aug 20262 sources0 comments

Methoxetamine (MXE) is an arylcyclohexylamine dissociative that emerged around 2010 as a 'research chemical' analogue of ketamine, marketed as bladder-friendly though this was never established. It has a longer duration and higher potency than ketamine and was linked to several deaths and hospitalisations before being widely banned.

01 Overview

MXE was one of the first novel dissociatives to gain popularity through online research-chemical vendors. Structurally related to ketamine and 3-MeO-PCP, it produces similar NMDA-antagonist dissociation but with slower onset and longer duration, which contributed to accidental redosing and overdose.

Human data are limited to case reports and toxicological series. Reported acute harms include severe dissociation, agitation, cerebellar signs (ataxia, slurred speech), tachycardia and hypertension. It was placed under international control after being associated with fatalities.

02 Mechanism

NMDA-receptor antagonist with additional serotonergic activity (serotonin transporter affinity), which may explain its longer, more stimulating profile compared with ketamine.

03 Dosing

Tier	Dose	Route	Notes
Light	5–15 mg	Insufflated
Common	15–40 mg	Insufflated	Long duration; delayed onset invites redosing.
Common	20–50 mg	Oral

04 Effects

Effect	Magnitude	Evidence
DissociationKetamine-like detachment, often described as longer and more euphoric.		Anecdotal
StimulationMore stimulating than ketamine, attributed to serotonergic activity.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Cerebellar toxicity (ataxia, dysarthria)Loss of coordination, slurred speech and nystagmus reported in acute intoxication.	Severe	Reported in toxicology series	Observational
Agitation and sympathomimetic toxicityTachycardia, hypertension and agitation, sometimes requiring hospital treatment.	Severe	Reported in case series	Observational

06 Legal status

United States

Possibly controlled as an analogue

May fall under the Federal Analogue Act. · as of Jan 2026

United Kingdom

Class B controlled drug

Controlled following an earlier temporary ban. · as of Jan 2026

07 References

Methoxetamine: toxicology and clinical case reportsPubMed literature

Methoxetamine reportEUDA (European Union Drugs Agency)

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.