Anabolic steroidAndrogenVeterinary17-alpha-alkylatedAndrostenediol derivative

Methandriol

Also known as Methylandrostenediol · Methandriol dipropionate · Stenediol · Probolic

Written by enwyReviewed 15 Jul 20261 sources0 comments

17-alpha-methylandrostenediol, a mild anabolic that is a methylated derivative of the testosterone precursor androstenediol. Sold historically for human use and still found in veterinary products, often as the dipropionate ester, it is regarded as weak but with a reputation for synergising other steroids.

01 Overview

Methandriol is 17-alpha-methyl-androst-5-ene-3-beta,17-beta-diol, essentially a 17-alpha-methylated form of androstenediol (a testosterone precursor). It was marketed for human anabolic therapy and persists in veterinary formulations, frequently as methandriol dipropionate for a depot effect.

It is a mild compound with modest androgenic and anabolic activity. Bodybuilding lore attributes to it a synergistic or potentiating effect when stacked with other androgens, though this is anecdotal. As a 17-alpha-alkylated steroid it carries hepatotoxic potential despite its weakness. Controlled human data are minimal; the profile rests on older sources, veterinary use and anecdote.

02 Mechanism

A weak androgen receptor agonist derived from androstenediol; 17-alpha-methylation gives oral/depot activity. It can convert peripherally toward more active androgens and has some estrogenic potential.

03 Dosing

Tier	Dose	Route	Notes
Anecdotal	25–75 mg/day	Oral	Oral use; hepatotoxic despite weakness.
Anecdotal (dipropionate)	100–300 mg/wk	IM	Mild compound; no controlled dosing data.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Mild anabolic effectModest lean-mass support reported anecdotally and in vintage use.		Anecdotal
Reputed synergy in stacksBodybuilding lore holds it potentiates co-administered androgens; unproven.		Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
HepatotoxicityLiver strain expected from 17-alpha-methylation.	Moderate	Class effect of 17aa orals	Anecdotal
Estrogenic effectsPossible gynecomastia and water retention.	Mild	Reported	Anecdotal
HPTA suppressionSuppression of endogenous testosterone.	Moderate	Expected	Anecdotal

06 Legal status

United States

Schedule III controlled substance

Anabolic steroid. · as of Jan 2026

07 References

Methandriol (methylandrostenediol) pharmacologyVintage and veterinary literature

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.