Anabolic steroidAndrogenOralDihydrotestosterone derivative1-methylated

Mesterolone (Proviron) Oral Tablet

Also known as Proviron · Mesterolone tablet

Written by enwyReviewed 5 Aug 20261 sources0 comments

This entry covers the oral tablet form of mesterolone, a 1-methyl dihydrotestosterone derivative marketed as Proviron. It is an orally active, non-17-alkylated androgen used clinically for hypogonadism and low libido, and non-medically as an anti-estrogenic ancillary and free-testosterone booster rather than a mass-building steroid.

01 Overview

Mesterolone is a 1-methylated DHT derivative that is orally active without 17-alpha-alkylation, giving it a low hepatic burden. Clinically it has been used for androgen deficiency, low libido and some cases of male infertility. It does not aromatise and binds strongly to sex-hormone-binding globulin (SHBG), which can raise free levels of co-administered androgens.

In physique circles the oral tablet is used less for muscle gain and more as an ancillary: to firm up physique, support libido during cycles, and act mildly against estrogenic effects. This entry emphasises the oral tablet pharmacology and dosing.

02 Mechanism

Androgen-receptor agonist; a 1-methyl-5-alpha DHT derivative that resists aromatisation and binds SHBG, indirectly raising free testosterone. Orally active without 17-alkylation.

03 Dosing

Tier	Dose	Route	Notes
Ancillary	25–100 mg/day	Oral	Non-medical ancillary use alongside other compounds.
Clinical	25–75 mg/day	Oral	FDA/EU range for androgen deficiency, often 25 mg 1-3x daily.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Improved libido and moodEffective for low libido and androgen-deficiency symptoms.	restored sexual function in hypogonadism	Clinical
Raised free testosteroneSHBG binding can increase the free fraction of other androgens.	via SHBG binding	Observational
Mild anti-estrogenic effectMay slightly reduce estrogenic effects during a cycle.	modest	Observational

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Androgenic effectsAcne, oily skin and possible hair-loss acceleration in predisposed users.	Mild	Dose-related	Clinical
HPTA suppressionSome suppression of endogenous testosterone, generally modest at typical doses.	Mild	Milder than most orals	Clinical

06 Legal status

United Kingdom

Class C

Prescription-only medicine (Proviron). · as of Jan 2026

United States

Schedule III controlled substance

Anabolic steroid definition; not FDA-marketed in the US. · as of Jan 2026

07 References

Mesterolone in the treatment of androgen deficiency and infertilityAndrologia / Journal of Clinical Endocrinology (historical)

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.