Research chemicalStimulantResearch chemicalPiperazine
MeOPP (pMeOPP)
Also known as MeOPP · pMeOPP · para-Methoxyphenylpiperazine · 4-MeOPP
MeOPP (para-methoxyphenylpiperazine) is a serotonergic phenylpiperazine that appeared as a minor party pill component. It is weakly active with little euphoria and sparse human data.
01 Overview
MeOPP (1-(4-methoxyphenyl)piperazine, also written pMeOPP) is a phenylpiperazine derivative that surfaced on the recreational market alongside BZP and TFMPP. It is a serotonergic agent rather than a strong stimulant.
Reports suggest it is relatively weak with limited recreational appeal, and dedicated human pharmacology is minimal. Its effects and risks are inferred largely from the broader phenylpiperazine class.
02 Mechanism
Acts as a serotonin releaser and receptor agonist, producing predominantly serotonergic rather than stimulant effects.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 50–150 mg | Oral | Anecdotal; reported as weak and unremarkable. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mild serotonergic effectSubtle mood and perceptual changes with little stimulation or euphoria. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Nausea and headacheNausea and headache reported, typical of serotonergic phenylpiperazines. | Mild | Common | Anecdotal | |
| Serotonergic interaction riskAs a serotonin releaser it carries theoretical serotonin toxicity risk with other serotonergic drugs. | Severe | Rare | Unconfirmed |
06 Legal status
UK
Class C (Misuse of Drugs Act)
Captured as a piperazine derivative. · as of Jan 2026
United States
Analogue exposure possible
Not explicitly scheduled federally; analogue provisions may apply. · as of Jan 2026
07 References
Methoxyphenylpiperazine pharmacologyPubMed
Piperazine derivatives drug profileEUDA (European Union Drugs Agency)
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.