LSM-775
LSM-775 is a lysergamide in which the diethylamide of LSD is replaced by a morpholide group. It is a lesser-known psychedelic reported to be shorter-acting and somewhat less potent than LSD, with a more sedated character. Human information is very limited and largely historical or anecdotal.
01 Overview
LSM-775 is the morpholide analogue of lysergic acid, differing from LSD by replacement of the diethylamide with a morpholine ring. It was investigated decades ago in early lysergamide structure-activity work and is now a rare research chemical distributed on blotter.
Reported effects are broadly psychedelic but described as shorter, milder and more sedating than LSD, with some reports emphasising a heavier or hazier quality. It has never been characterised in modern clinical studies; its profile rests on scattered historical reports and contemporary user accounts. Toxicity appears low at typical doses, with the usual psychedelic caveats around difficult experiences.
02 Mechanism
Agonist at serotonin 5-HT2A receptors, the shared mechanism of classical lysergamide psychedelics.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 100–300 mcg | Sublingual | Reported less potent than LSD; blotter potency uncertain. |
| Common | 300–700 mcg | Sublingual | Doses are approximate given scant data. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Visual alterationVisual distortions and enhancement, reported as gentler than LSD. | Milder than LSD | Anecdotal | |
| SedationA more sedated, hazy character than LSD. | Anecdotal | ||
| Mood changeAltered mood, variously euphoric or muted. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Anxiety and difficult experiencesAnxiety or challenging psychological experiences, especially at higher doses. | Moderate | Set-dependent | Anecdotal | |
| Cardiovascular stimulationIncreased heart rate and blood pressure. | Mild | Common | Anecdotal | |
| Persistent perceptual changes (HPPD)Rarely, lingering visual disturbances after use. | Moderate | Rare | Anecdotal |