SARMOralSARMAndrogen receptor modulatorQuinolinone

LG-121071

Also known as LG121071 · LG-121071

Written by enwyReviewed 15 Jul 20261 sources0 comments

LG-121071 is one of the earliest non-steroidal selective androgen receptor modulators, a quinolinone compound identified by Ligand Pharmaceuticals in the 1990s during the initial search for orally active tissue-selective androgens. It demonstrated anabolic activity in rodents but never advanced to human trials, and it is of largely historical and research interest.

01 Overview

LG-121071 belongs to the first generation of non-steroidal SARM chemotypes, predating the aryl-propionamide and later scaffolds that produced clinical candidates. As a quinolinone androgen receptor agonist, it showed that a fully non-steroidal molecule could stimulate androgen-dependent tissues.

In animal studies it produced anabolic effects on muscle with a different tissue profile than testosterone. It was a proof-of-concept tool compound rather than a drug candidate, and there is no published human pharmacology. It occasionally appears in grey-market listings on the strength of its historical SARM status.

02 Mechanism

A non-steroidal quinolinone androgen receptor agonist that activates the androgen receptor in muscle and bone with relative selectivity versus classic androgenic tissues in animal models.

03 Dosing

Tier	Dose	Route	Notes
Preclinical only	0 mg/day	Oral	No human dosing exists; studied only in animals.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Anabolic activity in muscleStimulated androgen-dependent muscle tissue in animal models.	Rodent	Preclinical
Tissue-selective androgen actionShowed a dissociated anabolic/androgenic profile relative to testosterone in early studies.	Preclinical	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Presumed HPTA suppressionAs an androgen receptor agonist it would be expected to suppress endogenous testosterone, though this is not documented in humans.	Moderate	Unknown	Unconfirmed
Unknown long-term safetyNo human safety data exists for this early tool compound.	Moderate	Unknown	Unconfirmed

06 Legal status

United States

Not approved; research chemical

Never developed for humans. SARMs are prohibited in sport by WADA (S1.2). · as of Jan 2026

07 References

Discovery of nonsteroidal androgen receptor modulators including LG121071Journal of Medicinal Chemistry / Ligand Pharmaceuticals research, 1990s

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.