PeptidePeptideReproductive hormoneGnRH secretagogue

Kisspeptin-10

Also known as Kisspeptin 10 · KP-10 · Metastin 45-54

Written by enwyReviewed 15 Jul 20261 sources0 comments

Kisspeptin-10 is a 10-amino-acid fragment of kisspeptin, an upstream regulator of GnRH release. In controlled human physiology studies it reliably stimulates LH and FSH secretion, and it is being investigated for reproductive and hypothalamic disorders. Its use as a self-administered testosterone-support peptide is off-label and far less validated than its research use.

01 Overview

Kisspeptin signals through the KISS1R receptor on GnRH neurons, sitting above GnRH in the reproductive axis. Human studies, including work from academic reproductive-endocrinology groups, have used kisspeptin-10 and related fragments to probe and stimulate the hypothalamic-pituitary-gonadal axis, and to explore treatment of infertility, hypothalamic amenorrhoea and related conditions.

This gives kisspeptin-10 a more substantial human evidence base than most peptides on this list, though as short-duration physiology and early clinical studies rather than approved chronic therapy. Its very short half-life and rapid desensitisation at high or continuous exposure complicate the bodybuilding idea of using it to sustain testosterone.

02 Mechanism

Binds KISS1R on hypothalamic GnRH neurons, stimulating pulsatile GnRH release and thereby downstream LH and FSH secretion from the pituitary.

03 Dosing

Tier	Dose	Route	Notes
Study-derived	100–1000 mcg	SubQ	Research studies use weight-based bolus or infusion dosing; single subcutaneous doses vary widely. No approved dosing for self-administration.

04 Effects

Effect	Magnitude	Evidence
Increased LH and FSH secretionReliably stimulates LH and FSH release in human physiology studies.	Reproducible gonadotropin rise	Clinical
Increased testosterone (indirect)Downstream testosterone rise follows gonadotropin stimulation in men in study settings.	Secondary to LH rise	Clinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Injection-site reactionsLocal irritation.	Mild	Common	Anecdotal
Receptor desensitisation with continuous/high dosingSustained or high-dose exposure can desensitise the axis, blunting the intended stimulatory effect.	Moderate	Dose/schedule-dependent	Clinical

06 Legal status

United States

Investigational; not approved as a drug

Used in research; not an approved therapeutic for self-administration. · as of Jan 2026

07 References

Kisspeptin-10 stimulates gonadotropin release in humansJournal of Clinical Endocrinology & Metabolism

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.