Research chemicalSympathomimetic amineBeta agonistSynephrine analog

Isopropylnorsynephrine (Deoxy)

Also known as Isopropyloctopamine · Deoxy · N-isopropyloctopamine · Isopropylnorsynephrine

Written by enwyReviewed 5 Aug 20261 sources0 comments

Isopropylnorsynephrine (isopropyloctopamine, 'Deoxy') is a synthetic beta-adrenergic sympathomimetic marketed in topical and oral fat-loss products for targeted lipolysis. It has essentially no human safety data and carries the cardiovascular cautions of potent beta-agonists.

01 Overview

Isopropylnorsynephrine is a synthetic analog of octopamine/synephrine designed as a beta-adrenergic agonist. It appears in 'stubborn fat' serums and some oral fat-burners, promoted for localised lipolysis when applied to skin.

Human research is absent, and its beta-agonist activity raises concerns about heart rate and blood pressure, especially in oral use or when stacked with other stimulants.

02 Mechanism

Beta-adrenergic receptor agonist that stimulates lipolysis in fat cells and can increase heart rate and cardiac output.

03 Dosing

Tier	Dose	Route	Notes
Oral (uncommon)	25–50 mg	Oral	Rare oral use; safety unknown.
Topical	100–250 mg/day	Transdermal	Applied topically in 'stubborn fat' serums; no validated dose.

04 Effects

Effect	Magnitude	Evidence
Localised lipolysisBeta-agonism may increase fat breakdown at application site.	Unclear	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
TachycardiaBeta-agonist activity can raise heart rate, especially with oral use or stacking.	Moderate	Unquantified	Preclinical
Blood pressure changesAdrenergic activity can alter blood pressure unpredictably.	Moderate	Unquantified	Preclinical

06 Legal status

United States

Not an approved dietary ingredient

Synthetic; status contested. · as of Jan 2026

07 References

Synthetic octopamine analogs in weight-loss productsPubMed

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.