Fluclotizolam
Fluclotizolam is a thienotriazolodiazepine designer benzodiazepine, closely related to clotizolam and etizolam. It is sold as a research chemical and reported to be extremely potent by weight, active in the low microgram-to-milligram range. There is no clinical human data; information comes from analytical work and user reports.
01 Overview
Fluclotizolam is a thienodiazepine, meaning it substitutes a thiophene ring for the benzene ring of classical benzodiazepines, and carries a triazole ring and fluorine substituent that raise its potency. It circulates on the research-chemical market and is noted for being active at very low doses, which makes accurate dosing without a precision scale hazardous.
Reported effects are strong sedation, anxiolysis, muscle relaxation and amnesia, typical of potent thienotriazolodiazepines. The extreme potency means misdosed pellets and powders readily cause over-sedation and blackouts. Dependence develops as with other benzodiazepines. No clinical characterisation exists.
02 Mechanism
Positive allosteric modulation of GABA-A receptors at the benzodiazepine site; the triazolothienodiazepine structure confers high potency.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 0.05–0.1 mg | Oral | Active in the microgram range; precision dosing essential. |
| Common | 0.1–0.3 mg | Oral | Small increases produce large effect changes. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| AnxiolysisStrong reduction of anxiety. | Marked | Anecdotal | |
| SedationPronounced drowsiness. | Strong | Anecdotal | |
| Muscle relaxationReduced muscle tension. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Dependence and withdrawalTolerance and dependence develop quickly; withdrawal can include seizures. | Severe | Common with regular use | Anecdotal | |
| Blackouts and misdosingExtreme potency makes accidental over-sedation and amnesia common. | Moderate | Common due to potency | Anecdotal | |
| Additive respiratory depressionDangerous with opioids or alcohol. | Life-threatening | With CNS depressants | Observational |