Ethylamphetamine
Ethylamphetamine (N-ethylamphetamine, etilamfetamine) is the N-ethyl homologue of amphetamine, briefly marketed as an anorectic under names such as Apetinil before falling out of use. It is a weaker, shorter-acting stimulant relative than amphetamine, with modest older clinical exposure but little modern data.
01 Overview
Ethylamphetamine replaces the N-methyl of methamphetamine (or the primary amine of amphetamine) with an N-ethyl group, which reduces central potency. It was one of several amphetamine-type anorectics sold mid-20th century for appetite suppression, so a limited historical clinical record exists, but it was largely abandoned as more selective agents appeared.
It is generally described as a milder, less euphoric stimulant than amphetamine. It remains a controlled substance in many jurisdictions and appears only occasionally as a research chemical today.
02 Mechanism
Substrate-type releaser of dopamine and noradrenaline, less potent centrally than amphetamine due to N-ethylation.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 20–50 mg | Insufflated | Unstudied route. |
| Common | 25–75 mg | Oral | Historical anorectic dosing was in this range; not a validated recreational guide. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Mild stimulationWeaker, shorter stimulation than amphetamine. | Anecdotal | ||
| Appetite suppressionThe basis for its historical use as an anorectic. | Observational | ||
| Increased wakefulnessReduced fatigue and increased alertness. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Tachycardia and hypertensionRaised heart rate and blood pressure typical of the class. | Severe | Common | Observational | |
| InsomniaSleep disruption after dosing. | Moderate | Common | Anecdotal | |
| Anxiety and restlessnessRestlessness and anxiety at higher doses. | Moderate | Common | Anecdotal |