DPT
DPT (N,N-dipropyltryptamine) is a synthetic psychedelic tryptamine. It has been used non-medically and, historically, in a small number of exploratory therapeutic and religious contexts. Human data are largely anecdotal with limited older clinical exploration; potency and duration vary by route, and dose responses differ widely between individuals.
01 Overview
DPT is a homologue of DMT with propyl groups on the nitrogen. Unlike DMT it is reported to be somewhat active orally, and is also used by insufflation. It was investigated in the mid-20th century in limited psychiatric and end-of-life research settings and has been used within at least one religious organisation.
Robust controlled human data are lacking. Reported effects are strongly psychedelic and can be intense and disorienting, with a variable and sometimes chaotic character. Dose responses vary widely and depend heavily on route; challenging psychological reactions are common at higher doses.
02 Mechanism
Serotonin 5-HT2A receptor agonist (classical psychedelic mechanism) with activity at additional serotonin receptor subtypes.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common (insufflated) | 20–60 mg | Insufflated | Faster, more intense onset; painful nasally. Not clinically validated. |
| Strong (insufflated) | 60–100 mg | Insufflated | Higher risk of overwhelming effects. |
| Common (oral) | 100–250 mg | Oral | Onset ~30-45 min, duration ~2-4 h. Highly approximate. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Intense psychedelic effectsStrong visual and cognitive alteration, sometimes described as chaotic or disorienting. | Anecdotal | ||
| Altered perception of self and realityProfound shifts in perception and thought, more pronounced at higher doses. | Anecdotal | ||
| Auditory effectsAuditory alterations and enhanced or distorted sound reported. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Nasal irritation (insufflated)Nasal pain and irritation reported with insufflation. | Mild | Common when insufflated | Anecdotal | |
| Cardiovascular stimulationIncreased heart rate and blood pressure. | Mild | Common | Anecdotal | |
| Challenging / frightening experiencesFear, confusion or panic, more likely given the intense and unpredictable character. | Moderate | Common at higher doses | Anecdotal |