DOM
DOM (2,5-dimethoxy-4-methylamphetamine), historically sold as STP, is a potent, long-lasting psychedelic amphetamine. It caused a wave of hospital admissions in the late 1960s when high-dose tablets were distributed. It is one of the better-studied DOx compounds, with some early human research, but remains hazardous due to slow onset, long duration and vasoconstriction.
01 Overview
DOM is a substituted amphetamine and 5-HT2A agonist that reached public attention in 1967 when tablets sold as 'STP' (Serenity, Tranquility, Peace) contained doses far higher than tolerable, producing prolonged, intense experiences and numerous emergency presentations. Because onset is slow, users at the time redosed, worsening the reactions.
DOM was subsequently studied to a limited degree in humans by Shulgin and others, making it one of the more characterised DOx compounds, though still far short of modern clinical standards. Effects last many hours; vasoconstriction and a long, stimulating tail are recognised features.
02 Mechanism
Potent, long-acting agonist at serotonin 5-HT2A receptors; the amphetamine backbone contributes stimulant effects and prolonged duration.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 1–2 mg | Oral | Slow onset; do not redose early. |
| Common | 3–8 mg | Oral | 1960s STP tablets contained far more, causing casualties. |
| Strong | 8–12 mg | Oral | Long, intense experience with increased vasoconstriction. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Long-lasting psychedeliaExtended visual and cognitive effects with stimulation. | strong | Anecdotal | |
| Very long durationHistorically responsible for prolonged emergency presentations. | 14-20 h | Observational | |
| Emotional and introspective depthStrong reflective states. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Insomnia and prolonged stimulationLong stimulating tail interferes with sleep. | Mild | Common | Anecdotal | |
| VasoconstrictionPeripheral vasoconstriction reported, consistent with the DOx class. | Moderate | Common, dose-dependent | Anecdotal | |
| Prolonged intense reactions requiring care1960s high-dose STP tablets produced numerous hospital admissions with agitation and prolonged psychosis-like states. | Severe | Common with high doses | Observational |