DOC
DOC (2,5-dimethoxy-4-chloroamphetamine) is a potent, very long-acting psychedelic amphetamine of the DOx family. Active in the low-milligram range with durations that can exceed 12-24 hours, it is known for strong visuals, marked stimulation and body load, and a long tail that makes dosing errors especially punishing.
01 Overview
DOC is a ring-substituted amphetamine acting as a 5-HT2A partial agonist, combining classic psychedelic effects with amphetamine-like stimulation. It is considerably more potent than the 2C-x compounds and much longer-lasting; a single dose can occupy a full day and night. Human research is essentially absent, and knowledge is anecdotal and forensic.
The extreme duration and strong stimulant character raise particular risks: prolonged vasoconstriction, insomnia, and a heightened chance of anxiety, paranoia or a protracted difficult experience. DOC has also been sold on blotter, where it can be mistaken for LSD, and has featured in poisonings and deaths linked to overdose and dosing errors.
02 Mechanism
Partial agonist at serotonin 5-HT2A receptors with amphetamine-like stimulant properties; the 4-chloro substitution on the DOx scaffold confers high potency and long duration.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 0.5–1 mg | Oral | Active in low-milligram range; long, slow onset. |
| Common | 1.5–3 mg | Oral | Full effect; expect a very long duration. |
| Strong | 3–5 mg | Oral | Intense and extremely long; high risk of distress and prolonged body load. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Strong visual effectsPronounced, long-lasting open- and closed-eye visuals. | Anecdotal | ||
| Stimulation and energyAmphetamine-like stimulation and wakefulness lasting many hours. | Anecdotal | ||
| Euphoria and introspectionPositive mood and deep headspace at well-judged doses. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Prolonged vasoconstriction and cardiovascular strainSustained vasoconstriction with raised heart rate and blood pressure over many hours; a distinct concern given the drug's length. | Severe | Common given long duration | Anecdotal | |
| Overdose from long onset / redosingThe slow onset invites premature redosing while the extreme duration compounds any overshoot; poisonings and deaths have been reported. | Severe | Common with dosing error | Observational | |
| Anxiety, paranoia and prolonged distressAnxiety, paranoia and difficult experiences that can persist for many hours because of the drug's length. | Severe | Common at higher doses | Anecdotal |