DMBA (AMP Citrate)
DMBA (1,3-dimethylbutylamine, sold as 'AMP Citrate') is a structural analog of DMAA introduced to supplements as a substitute stimulant. It has essentially no human safety data, and the FDA warned that it does not qualify as a dietary ingredient and poses cardiovascular risks.
01 Overview
1,3-Dimethylbutylamine differs from DMAA by one carbon and was marketed under the misleading name 'AMP Citrate' or as an extract of Pouchung tea. Analytical surveys found it in numerous pre-workout and weight-loss products, none supported by evidence of natural sourcing.
Because DMBA is a close analog of a compound tied to serious cardiovascular harm and has no meaningful safety testing in humans, the FDA issued warning letters in 2015 declaring products containing it adulterated.
02 Mechanism
Presumed indirect sympathomimetic like DMAA, increasing catecholamine signalling and raising heart rate and blood pressure.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 100–300 mg | Oral | Range found in labelled supplements; no established safe dose. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Perceived stimulationUsers report energy and focus, generally weaker than DMAA. | Mild-moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Anxiety and overstimulationRestlessness and anxiety typical of the stimulant class. | Mild | Common | Anecdotal | |
| Cardiovascular strainRaised heart rate and blood pressure expected from the DMAA-like structure. | Severe | Unquantified | Preclinical |