Research chemicalSympathomimetic amineBeta agonistUnapproved drug

Deterenol

Also known as Isopropylnorsynephrine (regulatory usage) · Isopropamine (misnomer) · beta-hydroxy isopropylnorsynephrine

Written by enwyReviewed 5 Aug 20261 sources0 comments

Deterenol (isopropylnorsynephrine's relative; isopropylamino-methylphenol ethanol) is an unapproved beta-adrenergic stimulant found illegally in weight-loss and pre-workout supplements. It is not approved for use in humans anywhere, and analyses have repeatedly flagged it in adulterated products alongside other banned stimulants.

01 Overview

Deterenol is a sympathomimetic that was studied decades ago but never approved for human use in the United States. Independent testing has found it in numerous supplements, frequently combined with other prohibited amines, prompting warnings from researchers and regulators.

Because it is an unapproved drug with a beta-agonist profile, its presence in supplements is considered adulteration, and it carries the cardiovascular risk typical of the class with no safety oversight.

02 Mechanism

Beta-adrenergic receptor agonist causing cardiovascular stimulation and lipolysis.

03 Dosing

Tier	Dose	Route	Notes
Found in products	5–50 mg	Oral	Amounts detected in adulterated supplements; no approved dose.

04 Effects

Effect	Magnitude	Evidence
StimulationMarketed for energy and fat loss; effects poorly documented.	Unclear	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Cardiovascular eventsBeta-agonist stimulation may cause tachycardia, arrhythmia and raised blood pressure.	Severe	Unquantified	Preclinical
Interaction with co-adulterantsOften found with other banned stimulants, compounding risk.	Severe	Unquantified	Observational

06 Legal status

United States

Unapproved drug / adulterant (FDA)

Not lawful in supplements; flagged as adulteration. · as of Jan 2026

07 References

Deterenol and other stimulants in over-the-counter weight loss and sports supplementsClinical Toxicology, 2021 (PubMed)

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.