Anabolic steroidAndrogenOral17-alpha-alkylatedDesigner steroid

Desoxymethyltestosterone

Also known as Madol · DMT · Pheraplex

Written by enwyReviewed 15 Jul 20261 sources0 comments

A synthetic oral androgen ('Madol', DMT) with no ester and no 3-keto group, identified by anti-doping labs in 2005 after being distributed as a designer steroid intended to evade detection. Preclinical assays suggested strong anabolic activity, but essentially no controlled human data exist.

01 Overview

Desoxymethyltestosterone (17alpha-methyl-5alpha-androst-2-en-17beta-ol) was never developed as a licensed drug. It surfaced as a 'gray-market' oral marketed to athletes, and its structure — lacking the 3-keto oxygen found in most androgens — was chosen to slip past standard screening. Rodent bioassays reported by anti-doping researchers implied a high anabolic-to-androgenic ratio.

Human use is limited to anecdotal reports from bodybuilding forums and seizures by regulators. Because it is 17alpha-alkylated and orally active, it carries the hepatotoxicity and suppression expected of that class, but no formal toxicology, pharmacokinetic, or efficacy trials in humans have been published.

02 Mechanism

Binds the androgen receptor as a direct agonist; the 5alpha-reduced, non-aromatisable structure means it does not convert to estrogen and acts primarily through AR-mediated anabolic signalling in muscle.

03 Dosing

Tier	Dose	Route	Notes
Anecdotal	10–30 mg/day	Oral	Forum-reported ranges only; no clinical dosing exists.

Ester comparison

Ester	Half-life	Injection freq.	Testosterone by mass

04 Effects

Effect	Magnitude	Evidence
Increased lean massUsers report rapid strength and size gains, consistent with a potent oral androgen, but no measured data exist.	unquantified	Anecdotal
Strong AR activation in preclinical assayAnimal bioassays reported strong myotrophic activity relative to androgenic effect.	high anabolic:androgenic in rodents	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
HPTA suppressionExogenous androgen shuts down endogenous testosterone production.	Severe	Expected	Anecdotal
Hepatotoxicity17alpha-alkylation is associated with liver strain and cholestasis.	Moderate	Class-typical	Preclinical

06 Legal status

United States

Schedule III anabolic steroid

Explicitly named under the Anabolic Steroid Control Act framework. · as of Jan 2026

07 References

Detection of the designer steroid desoxymethyltestosterone (madol) in urineRapid Communications in Mass Spectrometry, 2005

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.