Deschloroketamine (DCK)
Deschloroketamine (DCK) is a ketamine analogue lacking the chlorine atom, sold as a research chemical. It is more potent and longer-lasting than ketamine, and its long duration has been linked to compulsive redosing and prolonged dissociation.
01 Overview
DCK (2-phenyl-2-(methylamino)cyclohexanone) is structurally ketamine with the aromatic chlorine removed. It retains ketamine-like NMDA-antagonist dissociation but with greater potency and a substantially longer duration, which increases the risk of redosing before the previous dose has worn off.
Human information is limited to anecdote and scattered case reports. Reported effects mirror ketamine; the main distinguishing hazards are its long duration and reports of prolonged or unexpectedly intense states. Bladder toxicity of the ketamine type is plausible but not well documented for DCK.
02 Mechanism
NMDA-receptor antagonist, closely analogous to ketamine but with higher binding affinity and slower clearance.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Light | 10–25 mg | Oral | |
| Common | 15–40 mg | Insufflated | |
| Common | 25–60 mg | Oral | Long duration; wait before redosing. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| DissociationKetamine-like dissociation, reported as more potent and longer-lasting. | Anecdotal | ||
| Analgesia and sedationPain relief and sedation typical of the class. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Prolonged dissociation and redosingLong duration leads to compulsive redosing and extended, sometimes overwhelming dissociative states. | Moderate | Reported anecdotally | Anecdotal | |
| Possible bladder toxicityUrinary toxicity of the ketamine type is plausible but not established for DCK. | Moderate | Plausible, undocumented | Unconfirmed |