D2PM (Diphenylprolinol)
D2PM (diphenylprolinol, diphenyl-2-pyrrolidinemethanol) is a piperidine/pyrrolidine-based stimulant related to the pipradrol family, sold as a legal-high stimulant. It is a norepinephrine-dopamine reuptake inhibitor notable for a very long duration and case reports of severe, prolonged agitation and cardiovascular toxicity.
01 Overview
D2PM is structurally related to pipradrol and desoxypipradrol (2-DPMP), a class of long-acting reuptake inhibitors that appeared in 'legal high' products around 2010. It has been sold as a powder and in branded stimulant blends.
Human data is limited to emergency-department case reports, several describing prolonged agitation, hallucinations, tachycardia and insomnia lasting days due to the drug's long half-life. No formal pharmacokinetic studies exist. It is controlled in the UK.
02 Mechanism
Long-acting norepinephrine-dopamine reuptake inhibitor of the pipradrol/diphenylmethylpyrrolidine class.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common (approximate, anecdotal) | 5–20 mg | Oral | Very long duration; redosing dangerous. User-reported only. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Long-lasting stimulationExtended wakefulness and drive, often far longer than intended. | Strong | Anecdotal | |
| FocusIncreased concentration reported at lower doses. | Moderate | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Prolonged agitation and psychosisCase reports describe agitation, hallucinations and insomnia lasting days due to long half-life. | Severe | Common in reported intoxications | Observational | |
| Cardiovascular toxicityTachycardia and hypertension reported in intoxications. | Severe | Common in reported cases | Observational |