PeptideInjectableNeuroprotectiveBioregulator peptide

Cortagen

Also known as Cortexin analogue · AEDP peptide

Written by enwyReviewed 5 Aug 20261 sources0 comments

Cortagen (Ala-Glu-Asp-Pro) is a synthetic Khavinson bioregulator peptide claimed to support cerebral cortex and peripheral nerve function. Evidence is limited to Russian preclinical and small clinical reports from the originating group; independent human data are absent.

01 Overview

Cortagen was designed as a short synthetic analogue of a cortical peptide extract (cortexin). Developer-group studies report benefits in nerve regeneration and cortical function in animal models and some small clinical settings such as peripheral neuropathy.\n\nAs with the other Khavinson bioregulators, these findings have not been independently replicated in rigorous trials. It is sold as a research peptide with no regulatory approval outside Russia.

02 Mechanism

Proposed to regulate gene expression in neural tissue, supporting neuronal repair and cortical activity; human mechanism unconfirmed.

03 Dosing

Tier	Dose	Route	Notes
Anecdotal	2–5 mg/day	IM	Short cycled courses per vendor/Russian protocols.

04 Effects

Effect	Magnitude	Evidence
Peripheral nerve supportReported to aid nerve regeneration in animal models.	n/a	Preclinical
Cognitive/cortical supportClaimed cortical benefits; unverified in controlled human trials.	n/a	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Injection-site reactionLocal pain or irritation at injection sites.	Mild	Common	Anecdotal
Unknown human safetyNo independent human toxicology data.	Moderate	Unquantified	Unconfirmed

06 Legal status

United States

Research chemical; not FDA-approved

Research use only. · as of Jan 2026

07 References

Neuroprotective peptide bioregulators (Khavinson peptides) reviewBull Exp Biol Med

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.