PharmaceuticalSympathomimeticPsychostimulantLegacy analeptic
Clofenciclan
Also known as Clofenciclanum
Clofenciclan is an obscure CNS stimulant developed in the mid-20th century as an activating agent for fatigue and depressive states. It has minimal published data and is effectively obsolete; it is included here for completeness as a legacy focus/wakefulness stimulant.
01 Overview
Clofenciclan is a cyclopentyl aminoethyl ester stimulant that saw brief investigation as a psychostimulant/analeptic. Documentation is extremely limited and it was never widely marketed.
With almost no modern pharmacology or safety data, it is a historical footnote among mid-century stimulants rather than a current therapeutic. Any use would be uncharacterised.
02 Mechanism
Presumed indirect sympathomimetic/CNS stimulant; specific molecular targets are not well documented.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| No validated dose | 0 mg | Oral | No established modern dosing; historical use only, poorly documented. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| StimulationHistorical reports of increased arousal and reduced fatigue. | n/a | Observational | |
| Mood activationClaimed activating effect in depressive lethargy; unquantified. | n/a | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Insomnia / restlessnessSleep disturbance and nervousness expected of the class. | Mild | Reported | Observational | |
| Uncharacterised toxicityEssentially no human safety data. | Moderate | Uncharacterised | Unconfirmed |
06 Legal status
United States
Unapproved; not marketed
Obsolete; no current approval. · as of Jan 2026
United Kingdom
Unlicensed
No modern regulatory status. · as of Jan 2026
07 References
Clofenciclan chemical recordPubChem
Mid-century analeptic stimulants (context)Historical pharmacology
08 Discussion0 comments
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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.