CJC-1295 with DAC
CJC-1295 with DAC is a GHRH(1-29) analogue bearing a Drug Affinity Complex (a maleimidoproprionic acid group) that binds circulating albumin, extending its half-life to roughly a week. This produces a sustained 'GH bleed' rather than discrete pulses. Small early-phase human trials exist; broader clinical evidence is limited and non-medical use is off-label.
01 Overview
The DAC modification lets a single injection maintain elevated GH and IGF-1 for days by covalently attaching to albumin in vivo. Early clinical pharmacology studies in healthy adults showed dose-dependent, prolonged increases in GH and IGF-1 with weekly dosing.
Because it raises GH tonically rather than in pulses, some argue it departs further from physiological secretion than short-acting GHRH analogues, which may matter for feedback and side-effect profile. Human efficacy data for body composition remain thin, and the compound is not an approved medicine.
02 Mechanism
GHRH(1-29) analogue whose DAC linker binds serum albumin to resist clearance, giving sustained GHRH-receptor stimulation of the pituitary and a prolonged elevation of GH and IGF-1.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Anecdotal (non-medical) | 1–2 mg/wk | SubQ | Often ~1-2 mg once or twice weekly given the long half-life. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Sustained rise in GH/IGF-1Weekly dosing produced prolonged, dose-dependent GH and IGF-1 elevation in small healthy-adult studies. | IGF-1 up ~1.5-3x over baseline in early trials | Clinical | |
| Fat loss and recoveryReported body-composition and recovery benefits; not established by controlled efficacy trials. | Anecdotal | ||
| Improved sleepUsers report better sleep, consistent with GH-axis effects. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Water retention / oedemaFluid retention and puffiness from tonic GH exposure. | Moderate | Common with sustained GH elevation | Anecdotal | |
| Carpal-tunnel-like symptomsWrist/hand tingling from fluid retention. | Mild | Uncommon | Anecdotal | |
| Raised glucose / insulin resistanceSustained GH may reduce insulin sensitivity. | Moderate | Uncommon; more likely with tonic elevation | Preclinical |