Research chemicalResearch chemicalPsychedelicTryptamine

Baeocystin

Also known as Norpsilocybin · 4-Phosphoryloxy-NMT

Written by enwyReviewed 15 Jul 20261 sources0 comments

Baeocystin is a naturally occurring analogue of psilocybin found in Psilocybe mushrooms, differing by having a single N-methyl group (it is the N-desmethyl analogue of psilocybin). It is thought to be a prodrug for norpsilocin. Its independent psychoactivity in humans is poorly established and rests largely on a small amount of historical self-experimentation.

01 Overview

Baeocystin is a minor tryptamine alkaloid co-occurring with psilocybin and psilocin in many magic mushroom species. Structurally it is the mono-methylated counterpart of psilocybin, dephosphorylating to norpsilocin (4-HO-NMT). Its contribution to the overall effects of mushrooms, and its potency when isolated, remain uncertain.

Human data are extremely limited; older self-reports suggested some activity while its independent potency is debated. It is of interest mainly as a natural constituent and research target rather than a standalone recreational compound.

02 Mechanism

Presumed prodrug for norpsilocin, a serotonin 5-HT2A receptor agonist; its own human pharmacology is not well established.

03 Dosing

Tier	Dose	Route	Notes
Threshold	4–8 mg	Oral	Highly uncertain; independent potency is not well established.
Common	8–20 mg	Oral	Speculative; based on sparse historical reports.

04 Effects

Effect	Magnitude	Evidence
Psilocybin-like psychedelia (uncertain)Possible psychedelic activity when isolated, but its independent effect in humans is poorly established.	Uncertain	Unconfirmed
Contribution to mushroom effectsAs a natural constituent it may contribute to the overall mushroom experience alongside psilocybin and psilocin.	Minor	Preclinical

05 Side effects

Effect	Severity	Frequency	Evidence	Countermeasures
Nausea (presumed)Gastrointestinal upset is plausible as with other tryptamines.	Mild	Unknown	Unconfirmed
Anxiety (presumed)By analogy to related tryptamines, anxiety is plausible, but human data are lacking.	Moderate	Unknown	Unconfirmed

06 Legal status

United States

Not explicitly scheduled by name

Occurs in scheduled mushrooms; its standalone legal status is ambiguous and may fall under analogue provisions. · as of Jan 2026

07 References

Norpsilocin, the active metabolite of baeocystin, is a 5-HT2A agonistJournal of Natural Products / pharmacology literature

08 Discussion0 comments

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This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.