Research chemicalResearch chemicalPsychedelicTryptamine

αMT (Alpha-methyltryptamine)

Also known as AMT · Indopan · IT-290

Written by enwyReviewed 15 Jul 20261 sources0 comments

Alpha-methyltryptamine (AMT) is a long-acting tryptamine with mixed psychedelic, stimulant, and entactogenic effects. Originally investigated as an antidepressant in the Soviet Union (marketed as Indopan), it later re-emerged as a recreational research chemical. Its alpha-methyl group confers monoamine-releasing and MAOI activity and a long duration; it has been implicated in deaths, often involving drug interactions.

01 Overview

AMT was studied clinically as an antidepressant in the 1960s at low doses. At the higher doses used recreationally it produces a mixture of psychedelic, stimulant, and MDMA-like effects lasting 12-24 hours. The alpha-methyl substitution slows metabolism and gives the compound monoamine oxidase inhibitory properties.

That MAOI activity is the key hazard: combining AMT with SSRIs, other MAOIs, or serotonergic drugs risks serotonin toxicity, and several fatalities have involved such interactions or high doses. The long duration compounds the risk. It was placed in US Schedule I in 2003.

02 Mechanism

Non-selective monoamine releaser and reuptake inhibitor with serotonin 5-HT2A agonism and reversible monoamine oxidase inhibition; the alpha-methyl group slows metabolism and prolongs effects.

03 Dosing

Tier	Dose	Route	Notes
Light	10–20 mg	Oral	Anecdotal; stimulant-leaning at lower doses.
Common	20–40 mg	Oral	Anecdotal; full psychedelic/entactogenic effects, very long duration.

04 Effects

Effect	Magnitude	Evidence
Entactogenic / stimulant effectsMDMA-like emotional openness combined with stimulation, per user reports.	Variable	Anecdotal
Psychedelic effectsVisual and cognitive alteration at higher doses over a long duration.	Dose-dependent	Anecdotal

05 Side effects

Effect	Severity	Frequency	Evidence
Nausea and appetite lossNausea, especially during onset, and appetite suppression.	Mild	Common	Anecdotal
Prolonged insomnia and anxietyThe long stimulant duration frequently causes extended wakefulness and anxiety.	Moderate	Common	Anecdotal
Serotonin toxicity from interactionsMAOI activity makes combinations with serotonergic drugs dangerous; deaths have occurred.	Life-threatening	Reported in fatalities	Observational

06 Legal status

United States

Schedule I controlled

Placed in Schedule I in 2003. · as of Jan 2026

07 References

Alpha-methyltryptamine (AMT) toxicity and fatalities: case reportsJournal of Analytical Toxicology, 2000s

08 Discussion0 comments

Create account

Discussion is moderated. No sourcing, vendor names or price talk — those comments are removed, and repeat posts are banned.

This page is reference information, not medical advice. Doses and protocols are documented as they appear in the clinical literature and in practice — describing them is not a recommendation to use them. Countermeasures listed here are not a substitute for a physician. Legal status varies by jurisdiction and changes.