alpha-PBT
alpha-PBT (alpha-pyrrolidinobutiothiophenone) is a thiophene-based pyrrolidine synthetic cathinone, replacing the phenyl ring of alpha-PBP with a thiophene ring. Sold as a research chemical, it is presumed to act as a dopamine reuptake inhibitor. Human data is essentially absent and all information is anecdotal.
01 Overview
alpha-PBT is a thiophene analogue in the pyrrolidinophenone family, marketed as a legal-grey stimulant. The bioisosteric thiophene ring is intended to mimic the phenyl ring of alpha-PBP; users report a broadly similar potent, compulsive stimulant profile.
As a pyrrolidine cathinone it carries a heightened risk of compulsive redosing and binge use, plus cardiovascular strain, comedown and unknown neurotoxicity. No controlled human studies exist; figures are approximate.
02 Mechanism
Presumed noradrenaline-dopamine reuptake inhibitor at the dopamine and noradrenaline transporters, with the thiophene ring acting as a phenyl bioisostere.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Common | 7–20 mg | Insufflated | Very compulsive. |
| Common | 10–30 mg | Oral | Anecdotal; potent, start low. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Intense stimulationStrong energy and focus. | Anecdotal | ||
| EuphoriaDopaminergic mood elevation. | Anecdotal | ||
| Appetite suppressionMarked hunger reduction. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Compulsive redosingStrong redosing compulsion typical of pyrrolidine cathinones. | Severe | Near universal | Anecdotal | |
| Cardiovascular strainTachycardia and hypertension. | Severe | Common | Unconfirmed | |
| ComedownFatigue and low mood after use. | Moderate | Common | Anecdotal |