AL-LAD
AL-LAD (6-allyl-6-nor-LSD) is a lysergamide analogue of LSD carrying an allyl group in place of the N6 methyl. It is a potent psychedelic with an experience often described as slightly more visual and less anxiogenic than LSD, characterised in early animal work by Hofmann and later by Nichols but never clinically trialled.
01 Overview
AL-LAD is one of the better-known "designer" lysergamides, first prepared in academic laboratories exploring modifications of the LSD scaffold. It circulates as blotters and is one of the more commonly encountered LSD alternatives.
Reported effects resemble LSD with a comparable dose range but a subtly different character: many users describe more colourful visuals and a somewhat gentler headspace. All such comparisons are anecdotal; there are no controlled human studies, and the same core psychedelic risks apply.
02 Mechanism
Partial agonist at 5-HT2A and other serotonin receptors; the N6-allyl substitution modestly alters receptor interaction relative to LSD.
03 Dosing
| Tier | Dose | Route | Notes |
|---|---|---|---|
| Threshold | 10–25 mcg | Sublingual | Microdose range. |
| Common | 80–150 mcg | Sublingual | Full psychedelic dose; roughly LSD-comparable. |
| Strong | 150–300 mcg | Oral | Strong visual experience. |
04 Effects
| Effect | Magnitude | Evidence | |
|---|---|---|---|
| Enhanced visualsVivid colour and geometric visuals, often reported as more pronounced than LSD. | 6-10 h | Anecdotal | |
| Mood elevationEuphoria and emotional openness with a headspace often called clearer than LSD. | Anecdotal | ||
| Anxiety at high dosesOverwhelm and paranoia possible at strong doses or in poor settings. | Anecdotal |
05 Side effects
| Effect | Severity | Frequency | Evidence | Countermeasures |
|---|---|---|---|---|
| Sympathomimetic effectsRaised heart rate and blood pressure, pupil dilation and mild tremor. | Mild | Common | Anecdotal | |
| Acute psychological distressAnxiety, paranoia or a challenging experience during acute effects. | Moderate | Common | Anecdotal | |
| Persistent perceptual changes (HPPD)Lasting visual disturbances after use, as with other LSD-type drugs. | Moderate | Rare | Observational |